centipede sting Anticentromere antibody in patients without CREST – Annals of the …

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Centromere Antibody, IgG
0050714

Ordering Recommendation

Aid in diagnosis of systemic sclerosis (SSc). Negative results do not rule out SSc. Preferred test is Comprehensive Systemic Sclerosis Panel ( 3000480 ).

Mnemonic
ANTICENT

Methodology
Semi-Quantitative Multiplex Bead Assay

Performed
Sun-Sat

Reported
1-2 days

New York DOH Approval Status
This test is New York DOH approved.

Submit With Order

    ARUP Consult®
    Disease Topics

      Example Reports

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        • Interface Map

        Specimen Required
        29 AU/mL or lessNegative
        30-40 AU/mLEquivocal
        41 AU/mL or greaterPositive

        Interpretive Data
        When detected by this multiplex bead assay, the presence of centromere antibodies is mainly associated with CREST syndrome, a variant of systemic sclerosis (SSc). These antibodies target the centromere B, a dominant antigen of the centromeric complex associated with the centromere pattern observed in antinuclear antibody (ANA) testing by IFA. Centromere antibodies may also be seen in a varying percentage of patients with other autoimmune diseases, including diffuse cutaneous SSc, Raynaud syndrome, interstitial pulmonary fibrosis, autoimmune liver disease, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).

        A negative result indicates no detectable IgG antibodies to centromere B. If the result is negative but clinical suspicion for SSc is strong, consider testing for ANA by IFA along with other antibodies associated with SSc, including Scl-70, U3-RNP, PM/Scl, or Th/To.

        Note

        Hotline History
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        CPT Code(s)
        83516

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        Components
        Component Test Code*Component Chart NameLOINC
        0050714Centromere Ab, IgG29966-9

        * Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

        Aliases
        • ACA
        • Anti-centromere Antibodies
        • Anti-Centromere Antibody
        • Anticentromere Antibodies
        • Centromere Antibodies, IgG
        • CENTROMERE ANTIBODY
        • Centromere Autoantibodies
        • Centromere B
        • CREST
        • HEp-2